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Nanjing XFNANO Materials Tech Co Ltd
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BioMimetic Therapeutics
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Image Search Results
Journal: Scientific Reports
Article Title: Label-free Electrochemiluminescent Immunosensor for Detection of Prostate Specific Antigen based on Aminated Graphene Quantum Dots and Carboxyl Graphene Quantum Dots
doi: 10.1038/srep20511
Figure Lengend Snippet: SEM of rGO ( A ) and Au/Ag-rGO ( B ), TEM of Au/Ag-rGO/Aminated-GQDs/Carboxyl-GQDs ( C ).
Article Snippet: Aminated graphene, aminated
Techniques:
Journal: Scientific Reports
Article Title: Label-free Electrochemiluminescent Immunosensor for Detection of Prostate Specific Antigen based on Aminated Graphene Quantum Dots and Carboxyl Graphene Quantum Dots
doi: 10.1038/srep20511
Figure Lengend Snippet: EIS in the presence of 5.0 mmol/L [Fe(CN) 6 ] 3−/4− solution containing 0.1 mol/L KCl ( A ) and ECL intensity–potential curves in PBS containing 100 mmol/L K 2 S 2 O 8 with the potential range of −2.0 to 0 V ( B ). (a) bare GCE (b) Au/Ag-rGO/Aminated-GQDs/Carboxyl-GQDs/GCE ( c ) PSA antibody/Au/Ag-rGO/Aminated-GQDs/Carboxyl-GQDs/GCE (d) BSA/PSA/Au/Ag-rGO/Aminated-GQDs/Carboxyl-GQDs/GCE (e) PSA/BSA/PSA antibody /Au/Ag-rGO/Aminated-GQDs/Carboxyl-GQDs/GCE.
Article Snippet: Aminated graphene, aminated
Techniques:
Journal: Scientific Reports
Article Title: Label-free Electrochemiluminescent Immunosensor for Detection of Prostate Specific Antigen based on Aminated Graphene Quantum Dots and Carboxyl Graphene Quantum Dots
doi: 10.1038/srep20511
Figure Lengend Snippet: ECL intensity–potential curves ( A ), effect of pH ( B ) and the concentration of K 2 S 2 O 8 ( C ) on the ECL intensity. (a) bare GCE (b) Aminated-GQDs (2.5 mg/mL)/GCE (c) Carboxyl-GQDs (2.5 mg/mL)/GCE (d) Aminated-GQDs (2.5 mg/mL)/Carboxyl-GQDs (2.5 mg/mL)/GCE.
Article Snippet: Aminated graphene, aminated
Techniques: Concentration Assay
Journal: Nanomaterials
Article Title: Label-Free Electrochemical Aptasensor for Sensitive Detection of Malachite Green Based on Au Nanoparticle/Graphene Quantum Dots/Tungsten Disulfide Nanocomposites
doi: 10.3390/nano9020229
Figure Lengend Snippet: ( A ) TEM image of a tungsten disulfide (WS 2 ) nanosheet. ( B ) TEM image of graphene quantum dots-tungsten disulfide nanosheet composite film modified glassy carbon electrode (GQDs-WS 2 ). ( C ) TEM image of gold nanoparticles (AuNPs). ( D ) SEM image of AuNPs/GQDs-WS 2 nanocomposite.
Article Snippet:
Techniques: Modification
Journal: Nanomaterials
Article Title: Label-Free Electrochemical Aptasensor for Sensitive Detection of Malachite Green Based on Au Nanoparticle/Graphene Quantum Dots/Tungsten Disulfide Nanocomposites
doi: 10.3390/nano9020229
Figure Lengend Snippet: Cyclic voltammetry responses of the bare glassy carbon electrode (GCE) ( a ), WS 2 /GCE ( b ), GQDs-WS 2 /GCE (c), and AuNPs/GQDs-WS 2 /GCE ( d ) towards 0.5 mM MG in pH 7.4 phosphate buffer. Scan rate: 100 mV s −1 .
Article Snippet:
Techniques:
Journal: Nanomaterials
Article Title: Label-Free Electrochemical Aptasensor for Sensitive Detection of Malachite Green Based on Au Nanoparticle/Graphene Quantum Dots/Tungsten Disulfide Nanocomposites
doi: 10.3390/nano9020229
Figure Lengend Snippet: ( A ) Electrochemical impedance spectroscopy (EIS) spectra of the designed aptasensor at different modification stage. ( B ) CV responses of different modified electrode. ( a ) bare GCE, ( b ) AuNPs/GQDs-WS 2 /GCE, ( c ) aptamer/AuNPs/GQDs-WS 2 /GCE, ( d ) MCH/aptamer/AuNPs/GQDs-WS 2 /GCE, and ( e ) MG/MCH/aptamer/AuNPs/GQDs-WS 2 /GCE. The CV measurements were performed in 0.1M KCl solution containing 5 mM K 3 [Fe(CN) 6 ] at a scan rate of 50 mV s −1 .
Article Snippet:
Techniques: Impedance Spectroscopy, Modification
Journal: Nanomaterials
Article Title: Label-Free Electrochemical Aptasensor for Sensitive Detection of Malachite Green Based on Au Nanoparticle/Graphene Quantum Dots/Tungsten Disulfide Nanocomposites
doi: 10.3390/nano9020229
Figure Lengend Snippet: CV responses of the aptasensor toward blank control ( a ), 1.0 μM MG ( c ), and 10 μM MG (d). Curve b shows the CV response of the AuNPs/GQDs-WS 2 /GCE toward 1.0 μM MG in pH 7.4 phosphate buffer. Scan rate: 100 mV s −1 .
Article Snippet:
Techniques: Control
Journal: Communications Biology
Article Title: Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy
doi: 10.1038/s42003-020-1016-z
Figure Lengend Snippet: a Folic acid targeting ligand decorated self-assembled liposomal nanohybrid loaded multimode imaging probes, viz., gold nanoparticles (AuNPs as radiocontrast for X-ray computed tomography and reactive oxygen species scavenger) and graphene quantum dots (GQDs as fluorescent contrast for near-infrared fluorescence imaging and photothermal agent). Designed functional liposomal nanohybrids demonstrating photothermal response/heat and the generation of reactive oxygen species (ROS, considered as the side product of photothermal therapy) under near-infrared (NIR) light exposure. b NIR light mediated cancer therapeutic representation with tumor-bearing mice model using engineered liposomal nanotheranostic agents and targeted imaging bimodality of breast cancer through X-ray computed tomography (X-ray CT) and in vivo imaging system (IVIS). Liposomal nanotheranostics treated cancer cells displaying the production of ROS (green emission represents the presence of ROS captured by DCFDA (2′,7′-dichlorofluorescin diacetate) dye staining) during NIR light exposure, scale bar = 20 µm.
Article Snippet: Fig. 2 Transmission electron microscopic (TEM) images of engineered liposomal nanotheranostics showing spherical morphology. a , b TEM images showing the successful encapsulation of
Techniques: Imaging, Computed Tomography, Fluorescence, Functional Assay, In Vivo Imaging, Staining
Journal: Communications Biology
Article Title: Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy
doi: 10.1038/s42003-020-1016-z
Figure Lengend Snippet: a , b TEM images showing the successful encapsulation of graphene quantum dots (GQDs) in liposomal cavity, scale bar = 100 nm and 10 nm. c TEM imaging observation of gold nanoparticles (AuNPs) and graphene quantum dots (GQDs) encapsulated with liposomal nanohybrids named as NFGL, scale bar = 500 nm. d Selected area electron diffraction (SAED) pattern of NFGL nanohybrids, scale bar = 100 nm. e Microscopic image showing the distribution of parent liposomes (loaded with AuNPs and GQDs) with maintained spherical morphology, scale bar = 200 nm.
Article Snippet: Fig. 2 Transmission electron microscopic (TEM) images of engineered liposomal nanotheranostics showing spherical morphology. a , b TEM images showing the successful encapsulation of
Techniques: Encapsulation, Imaging, Liposomes
Journal: Communications Biology
Article Title: Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy
doi: 10.1038/s42003-020-1016-z
Figure Lengend Snippet: a Absorption spectra of parent liposome (loaded with AuNPs and GQDs), prepared graphene quantum dots (GQDs), and gold nanoparticles (AuNPs) and graphene quantum dots (GQDs) loaded liposomal nanohybrids named as NFGL at two different time points, viz., 0.5 h and 24 h, indicating the presence of multimode probes (GQDs and AuNPs) within liposomal particles. b Photoluminescence spectra of prepared graphene quantum dots, GQDs encapsulated liposomes, and engineered NFGL nanohybrids using 500 nm excitation wavelength, demonstrating better emissive property of fabricated nanotheranostics.
Article Snippet: Fig. 2 Transmission electron microscopic (TEM) images of engineered liposomal nanotheranostics showing spherical morphology. a , b TEM images showing the successful encapsulation of
Techniques: Liposomes
Journal: Communications Biology
Article Title: Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy
doi: 10.1038/s42003-020-1016-z
Figure Lengend Snippet: Elemental composition of gold nanoparticles (AuNPs) and graphene quantum dots (GQDs) encapsulated with liposomal nanohybrids (NFGL) analyzed through transmission electron microscopic (TEM) images showing the presence of nitrogen (N in maroon color), phosphorous (P in blue color), gold (Au in emerald color), and oxygen (O in pink color) elements with individual and merged imaging, scale bar = 300 nm.
Article Snippet: Fig. 2 Transmission electron microscopic (TEM) images of engineered liposomal nanotheranostics showing spherical morphology. a , b TEM images showing the successful encapsulation of
Techniques: Transmission Assay, Imaging
Journal: Communications Biology
Article Title: Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy
doi: 10.1038/s42003-020-1016-z
Figure Lengend Snippet: a Contrast measurements (also known as radiodensity) of designed gold nanoparticles (AuNPs) and graphene quantum dots (GQDs)-loaded liposomal nanohybrids named as NFGL at various concentrations (5–100 µg/mL) using a clinical TOSHIBA 64 CT clinical scanner with 5 mm slice thickness and 1 s rotation time compared with parent liposome (loaded with AuNPs and GQDs), revealing the presence of AuNPs (high electron coefficient and density) within the liposomal framework. b Emission performance of NFGL and compared with parent liposomes and PBS using the in vivo imaging system (IVIS) showing the better contrast ability for deep tissue penetration, and indicating the presence of GQDs within liposomal assembly. c Time-dependent photothermal transduction performance of NFGL nanohybrids at 0.5 mg/mL concentration using 750 nm of NIR light irradiation (1 W/cm 2 ) compared with parent liposome ( n = 3), ensuring the potential impact of phototriggered therapy. d Digital photographs showing dispersion of NFGL at ambient conditions, and during laser exposure after 1 h and 24 h of time periods.
Article Snippet: Fig. 2 Transmission electron microscopic (TEM) images of engineered liposomal nanotheranostics showing spherical morphology. a , b TEM images showing the successful encapsulation of
Techniques: Liposomes, In Vivo Imaging, Transduction, Concentration Assay, Irradiation, Dispersion
Journal: Communications Biology
Article Title: Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy
doi: 10.1038/s42003-020-1016-z
Figure Lengend Snippet: a Cancer cell imaging and cellular uptake of folic acid functionalized NFGL nanotheranostic agents (NFGL–FA) with 4T1 breast cancer cell lines with and without NIR light exposure (750 nm, 1 W/cm 2 for 10 min of exposure), scale bar = 10 µm. b Observations of produced reactive oxygen species (ROS, as a side product of photothermal therapy) during NIR light irradiation using various formulations of NFGL nanohybrids treated with 4T1 cancer cell lines; green emissive ROS are noticed by (2′,7′-dichlorofluorescin diacetate, DCFDA) dye staining. c Quantitative analysis of produced ROS from nanohybrids treated with breast cancer cells with and without NIR light irradiation ( n = 3). d Percentage cell viability of NFGL nanohybrids before and after folic acid functionalization and its major components (GQDs and AuNPs) using 24 h MTT assay at different concentrations (0.1–1 mg/mL, n = 3).
Article Snippet: Fig. 2 Transmission electron microscopic (TEM) images of engineered liposomal nanotheranostics showing spherical morphology. a , b TEM images showing the successful encapsulation of
Techniques: Imaging, Produced, Irradiation, Staining, MTT Assay
Journal: Communications Biology
Article Title: Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy
doi: 10.1038/s42003-020-1016-z
Figure Lengend Snippet: a Planned NIR light mediated phototriggered strategy for post-injected 4T1 tumor bearing mice showing enhanced tumor uptake of injected gold nanoparticles (AuNPs) and graphene quantum dots (GQDs) loaded liposomal nanotheranostics with folic acid functionalization (NFGL–FA). b Experimental flowchart from day 0 (cell culture) to tissue collection (36 days) followed by multimodal tumor diagnosis and biodistribution experiment setup. c Localized tumor diagnosis and specific biodistribution measurements after 48 h of time before and after NIR light exposure (750 nm, 1 W/cm 2 for 10 min) followed by whole body X-ray computed tomography scans with coronal and axial CT slices of mice body using TOSHIBA 64 CT scanner at 120 kVp tube voltage and 250 mA tube current with 5 mm slice thickness and 1 s rotation time. d Targeted deep tumor localization in mice body before and after NIR light exposure (750 nm, 1 W/cm 2 for 10 min) using the in vivo imaging system (IVIS). In both imaging modalities, pre-injected mice were considered as control groups.
Article Snippet: Fig. 2 Transmission electron microscopic (TEM) images of engineered liposomal nanotheranostics showing spherical morphology. a , b TEM images showing the successful encapsulation of
Techniques: Injection, Cell Culture, Biomarker Discovery, Computed Tomography, In Vivo Imaging, Imaging, Control
Journal: Communications Biology
Article Title: Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy
doi: 10.1038/s42003-020-1016-z
Figure Lengend Snippet: a Whole body in vivo imaging for site-selective 4T1 tumor diagnosis at various time points (1, 24, and 48 h) of intravenously injected gold nanoparticles (AuNPs) and graphene quantum dots (GQDs) loaded liposomal nanotheranostics with folic acid functionalization (NFGL–FA). b Ex vivo imaging of collected major organs and 4T1 tumor after 48 h from intravenously nanotheranostics injected animals. c Digital photographs of 4T1 tumor bearing mice during their therapeutic conditions after intravenous injection of NFGL–FA nanotheranostics (n = 3 mice per group) showing the successive tumor regression in various therapeutic conditions with good health of treated mice. d , e Measurements of tumor reduction by tumor volume (mm 3 , * p < 0.05) and tumor weight (gram, * p < 0.05, ** p < 0.01) analysis ( n = 3 mice per group) during various therapeutic conditions using different formulations of NFGL–FA nanotheranostics with and without NIR light exposure (750 nm, 1 W/cm 2 for 10 min), and compared with the control group of animals (pre-injected and untreated mice). f Digital photograph of collected tumors after various therapeutic assessments using different formulations of NFGL–FA nanotheranostics representing the promising tumor reduction and potential impact of phototriggered cancer therapy.
Article Snippet: Fig. 2 Transmission electron microscopic (TEM) images of engineered liposomal nanotheranostics showing spherical morphology. a , b TEM images showing the successful encapsulation of
Techniques: In Vivo Imaging, Biomarker Discovery, Injection, Ex Vivo, Imaging, Control
Journal: Communications Biology
Article Title: Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy
doi: 10.1038/s42003-020-1016-z
Figure Lengend Snippet: a Percentage of hemolysis efficacy of liposomes, gold nanoparticles (AuNPs), and graphene quantum dots (GQDs) loaded liposomal nanotheranostics (NFGL) before and after FA attachment at various concentrations (10–200 µg/mL, n = 3). b Body weight measurements of post-injected various mice groups ( n = 3). Both the analysis demonstrate the good biocompatibility and safety of engineered liposomal nanotheranostic agents.
Article Snippet: Fig. 2 Transmission electron microscopic (TEM) images of engineered liposomal nanotheranostics showing spherical morphology. a , b TEM images showing the successful encapsulation of
Techniques: Liposomes, Injection
Journal: Advanced Science
Article Title: Nature‐Inspired 3D Spiral Grass Structured Graphene Quantum Dots/MXene Nanohybrids with Exceptional Photothermal‐Driven Pseudo‐Capacitance Improvement
doi: 10.1002/advs.202204086
Figure Lengend Snippet: Electrochemical performance of the biomimetic structural GQDs/MXene photothermal SCs. CV profiles of the GQDs/MXene‐720° SC at different scan rates a) in the dark and b) under 1 solar illumination. c) Comparative CV curves at 10 mV s −1 of the device in the dark and under 1 solar illumination. d) GCD curves of the SC at various current densities in the dark and under 1 solar illumination. e) Rate capability and f) Nyquist plots of the device in the dark and under 1 solar illumination. g) Ragone plot of the biomimetic structural GQDs/MXene photothermal SC in comparison with other recently reported 3D‐printed or MXene‐based SCs. h) Cycling performance of the device at 0.2 A cm −2 in the dark and under 1 solar illumination.
Article Snippet: A
Techniques: Comparison
Journal: Advanced Science
Article Title: Nature‐Inspired 3D Spiral Grass Structured Graphene Quantum Dots/MXene Nanohybrids with Exceptional Photothermal‐Driven Pseudo‐Capacitance Improvement
doi: 10.1002/advs.202204086
Figure Lengend Snippet: Electrochemical performance of the biomimetic structural GQDs/MXene‐720° photothermal SC under sunlight with different power densities. a) Surface temperature, b) CV curves at 100 mV s −1 , c) GCD curves at 100 mA cm −2 , and d) Nyquist plots of the symmetric GQDs/MXene‐720° SC under solar illumination at different power densities. e) Schematic illustration of the structure‐enhanced solar thermal‐driven capacitance enhancement of the biomimetic structural GQDs/MXene photothermal SC.
Article Snippet: A
Techniques: